We are a biopharma company
focused on the development of
innovative botanical drugs
in oncology supportive care
and dermatology

We develop products where options are limited

Indications / Claims	Preclinical	Phase 1	Phase 2	Phase 3	Market	Brandnames	Partners

Hair Loss						CG 210 / qilib

Advanced Hair Loss						CG 428

Pediatric Alopecia Areata (AA)							Charité¹

Chemotherapy-Induced Alopecia (CIA)							CHUV²

Permanent CIA (PCIA)

Cancer Related Fatigue (CRF)

^{(1) “Clinical Research Center for Hair and Skin Science” / the “Charité-Universitätsmedizin Berlin” cooperates with Legacy in conducting a study with name “RAAINBOW”.}
^{(2) Centre Hospitalier Universitaire Vaudois (CHUV), Medical Oncology service of the Oncology Department of UNIL-CHUV}

Our work was presented at major scientific congresses.

Year	Country	Conference	Field

2017	Singapore	ESMO Asia 2017	Oncology supportive care
	Japan	10^th World Congress for Hair Research	Dermatology
	US	Multinational Association of Supportive Care in Cancer	Oncology supportive care
	Thailand	42nd Annual Scientific Meeting of the Dermatological Society of Thailand	Dermatology

2016	US	American Academy of Dermatology	Dermatology
	US	Alopecia Areata Research Summit NAAF	Alopecia Areata
	Greece	EADV	Dermatology
	Australia	Multinational Association of Supportive Care in Cancer	Oncology supportive care
	Thailand	41st Annual Scientific Meeting of the Dermatological Society of Thailand	Dermatology
	US	American Association for Cancer Research	Oncology supportive care

2015	Denmark	EADV	Dermatology
	US	Multinational Association of Supportive Care in Cancer	Oncology supportive care
	US	American Association for Cancer Research	Oncology supportive care
	US	National Consortium of Breast Centers	Oncology supportive care
	US	Young Survival Coalition	Oncology supportive care
	US	Oncology Nursing Society	Oncology supportive care

2014	Singapore	Singapore International Conference on Skin Research	Dermatology
	US	American Academy of Dermatology	Dermatology
	Serbia	EADV	Dermatology
	US	San Antonio Breast Cancer Symposium	Oncology supportive care
	US	Young Adult Cancer Alliance	Oncology supportive care
	Korea	World Congress for Hair Research	Hair Science
	US	Young Adult Cancer Alliance	Oncology supportive care
	US	Society of Integrative Oncology	Oncology supportive care
	US	World Congress on Breast Cancer	Oncology supportive care
	US	American Association for Cancer Research	Oncology supportive care
	US	Multinational Association of Supportive Care in Cancer	Oncology supportive care

2013	Turkey	EADV	Dermatology
	Scotland	World Congress for Hair Research	Hair Science
	US	American Association for Cancer Research	Oncology supportive care
	US	Multinational Association of Supportive Care in Cancer	Oncology supportive care

2012	Bahamas	International Society for Hair Restoration Surgery	Hair Science
2012	Japan	Japan Society of Clinical Hair Restoration	Hair Science

Publications

Cucé LC et al., Cellium® GC: evaluation of a new natural active ingredient in 210 mg/ml topical solution, through scalp biopsy. Surg Cosmet Dermatol 2011; 3(2): 123-128
Takeda A et al., CG210 Enables Finasteride 1mg Users to Further Improve Hair Pattern: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Hair Ther Transplant 2013; 3: 107
Katoulis AC et al. Efficacy and Safety of a topical botanical in Female Androgenetic Alopecia: A Randomized, Single- Blinded, Vehicle-Controlled Study Skin Appendage Disorders 2018; A: 160-165

Management

Saad Harti
Founder and CEO

Saad has started in the financial field, at Arthur Andersen. He later co-founded Altacare, a healthcare business development firm active in more than 50 markets. Saad has pioneered contraceptive-access programs in developing countries.
Saad is the founder of Legacy and manages the company.

Geert Cauwenbergh, Ph.D.
Partner

Geert founded Barrier Therapeutics, a dermatology company in 2001. After bringing Barrier to success it was acquired by Stiefel in 2008. Prior to founding Barrier, Geert was responsible for the worldwide research and development of all skin care products for the Johnson & Johnson consumer companies. He is a board member of several dermatology companies. He has authored more than 100 publications.
Geert is a shareholder of Legacy and acts as strategic and scientific advisor.

JiaWei Liu, Ph.D.
VP R&D

Active in international academic and pharmaceutical industry, JiaWei successfully developed quality research projects in Chinese Academy of Sciences, Geneva and Lausanne University Hospitals. He was previously responsible for new drug search & evaluation Asia at the Swiss drug development company Debiopharm Group.
He also engaged in teaching activities at Harvard Medical School in 2013 and 2014. As Legacy Healthcare’s Vice President, he is in charge of the company’s R&D activities.

Michel Chretienne, Pharm D.
VP Quality

Michel has served as Pharmaceutical Director and Pharmacist in charge at Hoechst Marion Roussel (Aventis) until 1999. Michel is involved in a number of professional and scientific societies such as the French Association of Regulatory Affairs, Member of the Ethic Committee and Mediation of the French pharmaceutical industry (CEMIP) etc.
Michel is responsible of the quality and manufacturing affairs of Legacy.

Nadine Vincent, Pharm D.
Head of Regulatory

Nadine has a pharmaceutical education and management training (INSEAD). She spent 30 years at Hoechst Marion Roussel, first in Research & Development and then as International Strategic Regulatory manager in charge of registering the key anti-infective products. She then joined HRA Pharma, where she stayed for over 15 years as Regulatory Affairs Director. Nadine has managed the registration of multiple products with EMA, FDA, PDMA, etc. Nadine is in charge of Regulatory Affairs.

Marcos Val
Chief Financial Officer

Marcos has spent over 15 years in corporate Healthcare and FMCG international finance leadership roles. In particular with Medtronic, as part of his Europe & Canada director role he supported the Biopharma Organization set up : pioneers in the launch of multi-million spine and neurocience drug products. Later in his career, he has successfully raised funds and coached healthcare startups while also carrying due diligence work for investor groups.

Bruce Patsner, M.D., J.D.
North American Operations Director

Active in women’s cancer care and medical research in the United States and Asia for 30 years, Bruce later trained in health law and Cal Berkeley and Harvard Law Schools; was a Senior Medical Officer at the United States FDA; and later worked in Pharmacovigilance at Genzyme/Sanofi in Cambridge, Massachusetts. He has extensive experience in clinical trial design and more than 100 publications in Oncology and food and drug law. Bruce is the Director of North American Operations for Legacy.

Tadafumi Shiiba
General Manager Japan

Tadafumi Shiiba, 44, General Manager for Legacy Healthcare KK (Japan), has accumulated experience working for medical corporations for more than 15 years. He served as sales representative at KOLs level in the fields of orthopedic surgery and gastroenterology at Smith & Nephew and Suzuken in Japan. He then joined Legacy Healthcare in 2012 first as a sales manager. He initially deployed CG 210 in several physician dispensing clinics and later on CG 428 in more than 60 oncology clinics. Thanks to his skills, Tadafumi managed to raise interest and convince two KOLs to conduct important self-funded clinical trials on the product in two hospitals in Japan.

Advisors and Investigators

Dr. med. Ulrike Blume-Peytavi
Clinical Research Centre for Hair and Skin Science
Charité-Universitätsmedizin, Berlin, Germany
Investigator for Pediatric Alopecia Areata
www.charite.de/service/person/person/address_detail/blume_peytavi/
Our research by Dr. Blume-Peytavi on ClinicalTrials.gov:
https://clinicaltrials.gov/NCT03240627?term=RAAINBOW&rank=1

Juhee Cho, PhD
Samsung Medical Center, Seoul, Korea
Investigator for Permanent Chemotherapy-Induced Alopecia
www.jhsph.edu/faculty/directory/profile/2323/juhee-cho
Our research by Dr. Cho on ClinicalTrials.gov:
https://clinicaltrials.gov/ct2/show/NCT02605629?term=CG428&rank=2
https://clinicaltrials.gov/ct2/show/NCT02986412?term=CG428&rank=1

Yasuyuki Kojima, MD, PhD
St. Marianna University School of Medicine, Tokyo, Japan
Investigator for Chemotherapy-Induced Alopecia
https://www.linkedin.com/in/yasuyuki-kojima-19b62324

Dr. Leorey N. Saligan
National Institutes of Health, Maryland, US
Investigator for Cancer-Related Fatigue
www.ninr.nih.gov/researchandfunding/dir/lsaligan

William Pralong, MD PhD
EPFL, Lausanne, Switzerland
Scientific Advisor
https://people.epfl.ch/william.pralong?lang=fr

Dr Philipp Spring
CEDDECC, Lausanne, Switzerland
Advisor for Chemotherapy-Induced Alopecia & Androgenetic Alopecia
http://www.ceddecc.ch/medecins/dr-philipp-spring.html

Dr. Khalil Zaman
CHUV, Lausanne, Switzerland
Investigator for Chemotherapy-Induced Alopecia
www.chuv.ch/oncologie/onc-equipe-dirigeante/onc-profil-zaman.htm
Our research by Dr. Zaman on ClinicalTrials.gov:
https://clinicaltrials.gov/NCT02919735?term=ELAN&draw=1&rank=2

Prof. Bianca Maria Piraccini
University of Bologna, Italy
Dermatology Department of Specialized, Experimental and Diagnostic Medicine
Investigator for Pediatric Alopecia Areata
www.unibo.it/sitoweb/biancamaria.piraccini/cv

Institutions & foundations we are proud to work with
The National Alopecia Areata Foundation (NAAF), San Rafael, US
http://www.naaf.org

Contact

Switzerland office
Rte de la Corniche 3B
1066 Epalinges (Lausanne)
Tel: +41 21 552 21 70
Email: contact@legacyhealthcare.ch

France office
27 Avenue de l'Opéra
75001 Paris - France
Tel: +33 1 70 38 54 83
Email: contact.fr@legacyhealthcare.ch

Japan office
TOC Daiichi Bldg. 6F
1-8-3 Shibuya, Shibuya-ku, Tokyo 150-0002
Tel: +81 3-6805-0651
Email: contact.jp@legacyhealthcare.ch